What is Aciclovir?

Aciclovir is an antiviral medicine used to treat infections caused by herpes simplex virus (HSV), including genital herpes. Genital herpes is usually caused by HSV-2, but HSV-1 (the cold sore virus) can also infect the genital area.

Genital herpes can cause:

• Painful blisters and sores on or around the genitals or anus
• Redness, irritation and soreness
• Flu-like symptoms (fever, aches, swollen glands), particularly during a first episode

Aciclovir tablets are a prescription-only medicine in the UK and are supplied following a clinical assessment by a qualified prescriber.

How does Aciclovir work?

Aciclovir works by stopping the herpes virus from multiplying inside infected cells. It interferes with the way the virus copies its genetic material (DNA), which:

• Shortens the length of an outbreak
• Helps blisters and sores heal more quickly
• Reduces pain, soreness and discomfort
• Reduces the amount of virus being shed during an episode

Aciclovir does not remove the virus from your body completely. The virus stays dormant in nerve cells and can reactivate, but treatment can make episodes shorter, milder and sometimes less frequent.

What is Aciclovir used for on this page?

On this product page, aciclovir tablets are used specifically for genital herpes in adults.

Other herpes virus infections (e.g. cold sores on the mouth, chickenpox and shingles) are outside the scope of this genital herpes service.

Who is this treatment suitable for?

Aciclovir tablets may be suitable for adults who:

• Have been diagnosed with genital herpes previously
• Have painful, bothersome or frequent recurrences
• Are able to take tablets regularly as prescribed
• Are not pregnant or breastfeeding
• Do not have significant kidney disease or other conditions that would make aciclovir unsuitable

Your prescriber will review your medical history, other medicines and symptoms to decide if aciclovir is suitable and which regimen is most appropriate.

Who should not take Aciclovir?

Aciclovir tablets may not be suitable if you:

• Are allergic to aciclovir, valaciclovir or any of the tablet ingredients
• Have kidney disease or significantly reduced kidney function
• Are elderly or frail, or at higher risk of dehydration
• Are pregnant, planning pregnancy or breastfeeding, unless a doctor has specifically advised that aciclovir is appropriate for you

You should also tell the prescriber if you are taking:

• Other antiviral medicines (e.g. valaciclovir, famciclovir)
• Medicines that may affect the kidneys (for example certain diuretics, ACE inhibitors, ciclosporin, tacrolimus)

Your clinician will assess your situation and may suggest alternative treatment or referral to your GP or a sexual health clinic if needed.

How do I take Aciclovir for genital herpes?

Your exact dose, frequency and length of course will be confirmed on your prescription. (your prescriber may adjust these to suit you).

General advice for taking Aciclovir

• Swallow tablets whole with water; they can be taken with or without food.
• Try to space doses evenly throughout the day (for example, morning–afternoon–evening).
• Drink plenty of fluids while taking aciclovir, especially if you are older or have any kidney issues.
• Never change your dose, stop long-term therapy suddenly, or extend a course without speaking to a healthcare professional.

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