Duac Once Daily Gel

  • Antibiotic Topical Acne Treatment
  • Active Ingredients: Clindamycin Phosphate and Benzoyl Peroxide
  • Treats Severe Acne
  • Buy With Confidence From UK Registered Pharmacy
  • Includes Free Prescription






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How does Duac gel work?

Duac once daily gel contains two active ingredients, clindamycin phosphate and benzoyl peroxide.

Benzoyl peroxide is a type of medicine known as a keratolytic. It works by breaking down keratin, a protein that forms part of the skin structure. When you apply benzoyl peroxide to the skin it causes the top layer of skin cells to break down and shed. This helps break down comedones (blackheads and whiteheads) and unblocks the sebaceous glands. It also helps to prevent the formation of new comedones.

Benzoyl peroxide also has an antibacterial action and directly kills the Propionebacterium acnes bacteria on the skin.

How long does Duac take to work?

The two active ingredients have a complementary effect on acne. It may take two to six weeks of treatment before the full effect of both medicines on the acne is seen, so it’s important to persevere with using the gel and be patient. If you haven’t seen any improvement after six weeks of use you should get advice from your doctor.

How do I use Duac?

You should Wash your skin with a mild cleanser and pat it dry before applying the gel.

Apply the gel thinly to the whole affected areas of skin (not just the individual spots) once a day in the evening. If the gel doesn’t rub in easily you are applying too much.

Avoid getting the gel in contact with your eyes, mouth, lips and mucous membranes such as the pning of the nose. Rinse the gel off thoroughly with water if you accidentally get it on these areas.

Avoid applying the gel to broken, irritated or sunburnt skin.

Wash your hands after applying the gel.

Benzoyl peroxide can be irritating to your skin. If you experience excessive redness, dryness or peeping of your skin after using Duac, decrease the amount of gel you use and use it less frequently (or stop temporarily). If any soreness persists consult your doctor.

Do not use this product excessively – this won’t make it any more effective but will increase the chance of it irritating your skin.

Do not use for longer than 12 weeks at a time.

Important information about Duac

Benzoyl peroxide can make your skin more sensitive to sunlight. Avoid exposing the treated areas of skin to excessive sunlight, or to sunbeds or sunlamps. If you can’t avoid sun exposure you should wear appropriate protective clothing such as a hat, or use a suitable sunscreen lotion.

This product may bleach hair and coloured fabrics including clothing, towels and bed linen. Be careful to avoid getting the gel on these materials.

When clindamycin is taken by mouth it can sometimes cause inflammation of the bowel (colitis). Although this is very unlikely to occur when you use the antibiotic on the skin, if you get diarrhea either during or after using Duac gel, particularly if it becomes severe or persistent or contains blood or mucus, you should stop using it and consult your doctor immediately.



Additional information

Weight N/A

3%, 5%


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Acne is a common skin condition that affects most people at some point. It causes spots, oily skin and sometimes skin that’s hot or painful to touch.

Acne most commonly develops on the:

Face this affects almost everyone with acne
Back this affects more than half of people with acne
Chest this affects about 15% of people with acne

Types of spots

There are six main types of spot caused by acne:

Blackheads small black or yellowish bumps that develop on the skin; they’re not filled with dirt, but are black because the inner lining of the hair follicle produces pigmentation (colouring).

Whiteheads have a similar appearance to blackheads, but may be firmer and won’t empty when squeezed.

Papules small red bumps that may feel tender or sore.

Pustules similar to papules, but have a white tip in the center, caused by a build-up of pus.

Nodules large hard lumps that build up beneath the surface of the skin and can be painful.
Cysts the most severe type of spot caused by acne; they’re large pus-filled lumps that look similar to boils and carry the greatest risk of causing permanent scarring.

What can I do if I have acne?

These self-help techniques may be useful:

Don’t wash affected areas of skin more than twice a day. Frequent washing can irritate the skin and make symptoms worse.

Ensure that you wash the affected area with a mild soap or cleanser and lukewarm water. Using very hot or cold water can make your acne worse.

Do not try to “clean out” blackheads or squeeze spots as this can make them worse and lead to permanent scarring.

Try to avoid using too much make-up and cosmetics which can aggravate your skin.

Use water-based products that are described as non-comedogenic -these products are formulated not to cause blocked pores.

Make sure you remove make-up completely before going to bed.

If you suffer from dry skin, use a fragrance-free, water-based emollient.

Whilst regular exercise does not improve acne, it can boost your mood and improve your self-esteem. Make sure you shower as soon as possible after exercising, as sweat can irritate your acne.

Wash your hair regularly and try to avoid letting your hair fall across your face.

Whilst acne cannot be cured, it can be treated and controlled with treatment such as creams, lotions and gels specifically designed for acne.

If you develop acne it is best to consult your pharmacist for advice. They may recommend products containing a low concentration of benzoyl peroxide (this must be used carefully as the ingredient can bleach clothing).

If you develop severe acne or it begins to appear on your chest and back, it may require treatment with antibiotics or stronger creams which will only be available through prescription.

Please note treatments can take up to three months to begin to show results. Once they do, the effects can be very promising.

Who is affected by acne?

Acne is most common in teenagers and younger adults with around 80% of people who suffer aged 11 to 30 years old. Most people will have acne for several years intermittently before their symptoms will begin to improve as they get older and tends to be resolved by their mid-twenties.


Your doctor will be able to diagnose acne by examining your skin, this will involve assessing your face, chest and back for different types of spots such as blackheads, whiteheads or nodules. The number of spots you have and the degree of how painful and inflamed they are will determine how severe your acne is and will determine the course of treatment you need.

There are four grades used to measure the severity of acne:

Grade 1 (mild) acne is mostly confined to whiteheads and blackheads, with just a few papules and pustules
Grade 2 (moderate) there are multiple papules and pustules, which are mostly confined to the face
Grade 3 (moderately severe) there’s a large number of papules and pustules, as well as the occasional inflamed nodule, and the back and chest are also affected by acne
Grade 4 (severe) there’s a large number of large, painful pustules and nodules

Acne in Women

For support and to read about other people’s experiences of living with and coping with acne, there are several blogs and sites on the internet such as talk health which provides free acne support. The Mix also has a website and helpline for teenagers and young people who may be struggling emotionally with acne issues and other difficulties.

Make-up can help cover up scars, particularly those on the face. You can buy camouflage make up over the counter which is specifically designed to cover up scars. You can also consult your doctor for further advice and support.

If you are interested in learning more about covering a mark, scar, non-infectious skin condition or a tattoo, you can also visit the Changing Faces skin camouflage service or call 0300 012 0276.

Side Effects

Possible side effects

Like all medicines, this medicine can cause side effects, although not everybody gets them.

Stop using DUAC ONCE DAILY GEL and see a doctor straight away if you notice any of the
following serious side effects – you may need urgent medical treatment:

Signs of an allergic reaction (such as swelling of your face, eyes, lips or tongue, nettle rash or difficulty
breathing, collapse)

Severe or prolonged diarrhoea, or abdominal cramps

Severe burning, peeling, or itching

Other possible side effects:

If you notice any of these side effects, try using DUAC ONCE DAILY GEL less often, or stop using it for
one or two days and then start again.

Very common side effects

(at least 1 in 10 people are affected)
At site of application:

Skin burning sensation, peeling, itching, dry skin
Redness of your skin, especially during the first few weeks of use

These side effects are generally mild.

Common side effects

(less than 1 in 10 people are affected)


At the site of application:

Sensitivity to sunlight, skin pain
Red, itchy skin, rash (dermatitis)

Uncommon side effects

(less than 1 in 100 people affected)

At the site of application:

Tingling (paraesthesia), worsening of acne

Other side effects have occurred in a very small number of people but their exact frequency is unknown:

Allergic reactions

Inflammation of the intestine, diarrhoea, including bloody diarrhoea, stomach pain

At the site of application:

Skin reactions, discoloration of the skin

Raised itchy rash (hives)

Further Information

Further information can be found on the manufacturers

Paitient Information Leaflet

and printed if required.